Welcome aboard Bouse!
I pondered all three thumpers before going the 450b route. It is a great round for hunting. You can run it fast and flat with 200gr bullets clocking out the tube at 2500fps or go big and slow, depeding upon what you want to hunt with it. I use it for deep woods/brush hunting where the odds of a shot beyond 75 yards are low. There are more range reports on loads that you can do here, already cut and tried, than almost anywhere else. Folks here are for the most part "friendly to a fault" and more than willing to advise on just about any aspect from experience, not just theory, though some of that abounds as well. We try to adhere to a zero troll tolerance also. No snarky comments. It is almost like a community of friends and that's getting harder to find thee days. More hunters than "Mall Ninjas". Ambiance aside, there are some sharp cookies here. We won't steer you wrong. I personally have loaded over 20 different bullets in this caliber and I find remarks on other forums that "We're so limited in bullet selection." to be rubbish. That's just other caliber fanboys being defensive of their particular choices. We love all thumpers, though the lion's share of the experience base here is with this caliber.
You will not go wrong with this caliber for hunting any creature in the continent, albeit, not at 300 or 7mm Mag distances. Whether you go with a factory rig or roll your own, choices have grown exponentially since I first got involved 7 years ago.
In Theory, there is no difference between theory and practice. In Practice, there is.