In the December edition of Petersens "Hunting" magazine - page 36; Dynamic Research Technology has developed a new .451 muzzel loader bullet they call the TSMZ. Most of their other bullets are designed to fragment completely, but they say this is not the case with the new TSMZ bullet.
Apparently they can compress the core materials to program predictable fragmentation for multiple wound channels and a programed predictable penetration of 14 - 16 inches for these sub-particles, but the bottom third of the core exits the animal completely. According to them, the animal absorbes nearly every foot pound of energy from the shot.
Here is their website:
http://drtammo.com/featured-products/tsmz/
Not being a reloader, I don't have answers to your questions, but I am interested in the answers you do find.
Bill